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. 2021 Dec 17;28(5):667–679. doi: 10.1093/ibd/izab292

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© 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 2. — Characterization of fibrotic response in transforming growth factor β (TGFβ)–treated induced pluripotent stem cell–derived mesenchymal cells over time. Fold-change increases in (A) N-cadherin, (B) Col1a1, (C) Col5a1, and (D) TIMP1 were assessed after 8, 24, and 48 hours of TGFβ (1ng/mL) treatment. Data were obtained from 16 independent experiments whereupon mesenchymal cells were obtained from 4 passages of induced pluripotent stem cell–derived organoids, and each passage was examined 4 times. Data obtained from a 2-way analysis of variance with a post hoc Dunnett’s test was carried out to determine for statistical significance in the 8-, 24-, and 48-hour time points as compared with each respective control (time 0) time point. ∗P < .05.