Table 4. The top three most similar pairs of STN based on the H_JS distance of the three-node subgraphs and four-node subgraphs normalized frequency distributions.

Network A	Network B	HJS distance	Absolute value of the difference of the subgraph normalized frequency distributions
3-node subgraph ID			(ID 6, ID 12, ID 36, ID 38)
Sphingolipid signaling pathway	TGF-beta signaling pathway	0.0263	(0.001, 0.029, 0.026, 0.005)
ErbB signaling pathway	Hippo signaling pathway	0.0312	(0.015, 0.017, 0.037, 0.005)
PI3K-Akt signaling pathway	Ras signaling pathway	0.0330	(0.010, 0.010, 0.007, 0.007)
4-node subgraph ID			(ID 14, ID 28, ID 74, ID 76, ID 78, ID 280, ID 328, ID 392, ID 2184)
Neurotrophin signaling pathway	Ras signaling pathway	0.115	(0.034, 0.030, 0.033, 0.026, 0.018, 0.024, 0.019, 0.008, 0.001)
Adipocytokine signaling pathway	B-cell receptor signaling pathway	0.119	(0.017, 0.054, 0.035, 0.034, 0.001, 0.013, 0.012, 0.031, 0.007)
Apelin signaling pathway	Chemokine signaling pathway	0.131	(0.045, 0.037, 0.011, 0.016, 0.005, 0.029, 0.010, 0.016, 0.007)