Table 5. The top three most similar pairs of cellular processes based on the H_JS distance of the three-node subgraphs and four-node subgraphs.

Network A	Network B	HJS distance	Absolute value of the difference of the subgraph normalized frequency distributions
3-node subgraph ID			(ID 6, ID 12, ID 36, ID 38)
Cell-cycle	Cellular senescence	0.0697	(0.015, 0.078, 0.090, 0.004)
Apoptosis	Focal adhesion	0.0839	(0.095, 0.037, 0.041, 0.015)
Cellular senescence	Focal adhesion	0.106	(0.059, 0.098, 0.002, 0.034)
4-node subgraph ID			(ID 14, ID 28, ID 74, ID 76, ID 78, ID 280, ID 328, ID 392, ID 2184)
Cell-cycle	Cellular senescence	0.125	(0.003, 0.0002, 0.001, 0.027, 0.001, 0.004, 0.057, 0.035, 0.039)
Apoptosis	Focal adhesion	0.143	(0.048, 0.013, 0.005, 0.041, 0.004, 0.023, 0.032, 0.016, 0.047)
Cell-cycle	Focal adhesion	0.205	(0.034, 0.047, 0.035, 0.008, 0.010, 0.083, 0.028, 0.054, 0.024)