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Common genomic alterations present at baseline (pre-ICI) and during or completion of ICI therapy (post-ICI).
| Gene | Pre-ICI, n (%) | Post-ICI, n (%) |
|---|---|---|
| TP53 | 21 (54) | 21 (54) |
| TERT | 19 (49) | 23 (59) |
| BRCA1/BRCA2 | 13 (33) | 13 (33) |
| CCND1/CCND2/CDKN2A/CDK6 | 6 (15) | 4 (10) |
| RAS | 5 (13) | 4 (10) |
| PIK3CA | 5 (13) | 5 (13) |
| EGFR | 3 (8) | 4 (10) |
| FGFR2/3 | 3 (8) | 5 (13) |
| ERBB2 | 1 (3) | 1 (3) |
| Rb | 1 (3) | 3 (8) |
| ALK | 1 (3) | 2 (5) |
Abbreviation: ICI, immune checkpoint inhibitor.
