Table 1.
Characteristics of Sham and AB rats
| Animal characteristics | Sham | AB |
|---|---|---|
| Body weight (BW) (g) | 422 ± 5 | 378 ± 11* |
| Heart weight (g) | 1.93 ± 0.11 | 3.33 ± 0.34* |
| Lung weight (g) | 1.73 ± 0.06 | 3.46 ± 0.16* |
| HW/BW (g/kg) | 4.1 ± 0.3 | 7.9 ± 0.5* |
| M-mode | ||
| IVSd (mm) | 1.3 ± 0.0 | 1.8 ± 0.1* |
| PWd (mm) | 1.4 ± 0.1 | 2.4 ± 0.1* |
| LVDd (mm) | 8.1 ± 0.2 | 9.0 ± 0.2* |
| LVDs (mm) | 4.8 ± 0.1 | 6.1 ± 0.5 |
| FS (%) | 40 ± 1 | 33 ± 5 |
| LAD (mm) | 3.4 ± 0.2 | 7.3 ± 0.4* |
| Doppler recordings | ||
| Peak mitral flow (m/s) | 1.13 ± 0.06 | 1.57 ± 0.06* |
| Mitral deceleration (mm/s2) | 3.5 ± 0.5 | 7.5 ± 0.6* |
| Peak RVOT (m/s) | 0.9 ± 0.0 | 0.9 ± 0.1 |
| Heart rate (bpm) | 366 ± 11 | 308 ± 6* |
| Maximal tissue velocity (mm/s) | 53 ± 2 | 35 ± 1* |
| Minimal tissue velocity (mm/s) | 53 ± 4 | 45 ± 5 |
BW, body weight; FS, fractional shortening; HW, heart weight; IVSd, intraventricular septum in diastole; LAD, left atrium diameter; LVDd/s, left ventricular diameter in diastole or systole; LW, lung weight; PWd, posterior wall in diastole; RVOT, right ventricular outlet tract.
In Sham and AB rats. *P < 0.05 vs. Sham (unpaired, two-sided t-test). n = 6 in both groups.