Table 3.
Pharmacokinetic parameters of carvedilol and 4/-hydroxyphenyl carvedilol after administration of a single 6.25 mg carvedilol orally.
| Parameters | Carvedilol | 4/-Hydroxyphenyl carvedilol | ||
|---|---|---|---|---|
|
| ||||
| Mean geometric (SD) | Range (min-max) | Mean geometric (SD) | Range (min-max) | |
| Tmax (h) | 0.78 (0.34) | 0.33 - 2.00 | 0.79 (0.32) | 0.33 - 2.00 |
| Cmax (ng/mL) | 21.26 (9.23) | 8.67 - 44.94 | 2.42 (2.07) | 0.73 - 9.56 |
| AUC0-t (ng.h/mL) | 66.95 (29.45) | 26.39 - 140.67 | 5.93 (3.06) | 1.98 - 15.24 |
| AUC0-inf (ng.h/mL) | 68.54 (30.11) | 27.16 - 143.94 | 6.78 (3.49) | 2.23 - 18.13 |
| T1/2 (h) | 6.30 (1.95) | 2.82 - 12.04 | 6.31 (6.45) | 2.34 – 24.34 |
| Clearance (L/h) | 22.79 (12.05) | 10.86 - 57.54 | ||
| volume of distribution (L) | 208.75 (126.78) | 98.07 - 549.98 | ||
Tmax, Time to peak plasma concentration; Cmax, peak plasma concentration; AUC, area under the curve.