Table 1.
KO Mice Exhibited Concentric Hypertrophy and Abnormal Maternal Cardiovascular Adaptation to Pregnancy, Which Was Rescued With Ascorbate Treatment
| Nonpregnant | Pregnant | Ascorbate‐treated pregnant | ||||
|---|---|---|---|---|---|---|
| B6 | Knockout | B6 | Knockout | B6 | Knockout | |
| Maternal body weight, g | 20.3±0.36* | 20.3±0.70* | 35.4±0.56 | 31.1±1.55 † | 36.24±0.78 | 34.2±0.55* |
| Heart rate, bpm | 454±9 | 497±18 | 494±14 | 498±12 | 484±7 | 517±14 |
| LV end‐diastolic dimension, diastole, mm | 3.40±0.04* | 3.50±0.05 | 3.78±0.04 | 3.52±0.12 † | 3.67±0.07 | 4.00±0.09* , † |
| LV anterior wall thickness, diastole, mm | 0.80±0.02 | 0.82±0.04* | 0.91±0.03 | 1.07±0.07 † | 0.84±0.03 | 0.88±0.04* |
| Relative wall thickness | 0.43±0.01 | 0.45±0.02* | 0.41±0.01 | 0.56±0.04 † | 0.44±0.01 | 0.45±0.03* |
| Myocyte length, µmol/L | 138±2* | 164±4* , † | 158±2 | 154±2 | 158±7 | 150±2 |
| Myocyte width, µmol/L | 25.7±0.28 | 25.1±0.46* | 25.2±0.53 | 29.4±0.67 † | 25.3±0.34 | 22.4±0.29* , † |
| Stroke volume, µL | 27.1±0.50* | 27.8±1.16 | 39.2±1.96 | 30.9±1.27 † | 34.5±1.54* | 40.1±1.60* , † |
| Heart weight normalized to tibal length, mg | 5.88±0.13* | 7.09±0.31* , † | 7.07±0.10 | 7.98±0.34 † | 7.01±0.63 | 9.98±3.38 † |
Results are shown as mean±SEM. Two‐way ANOVA with Newman‐Keuls for post hoc analysis. LV indicates left ventricular.
*
P<0.05 vs pregnancy (same strain).
†
Vs strain difference.