Figure 2. Muscle Na⁺ and creatinine clearance during the HS diet challenge.

Ratio of muscle Na⁺ to water (A and B) and creatinine clearance (C and D) in male and female Sprague Dawley rats during the NS diet phase or on day 1 of the HS challenge (n=5–8 rats in each group). Statistical comparisons were performed by 2‐way ANOVA with Sidak’s post hoc test for multiple comparisons. ANOVA results: muscle Na⁺: P _interaction=0.9, P _time=0.5, P _sex=0.2; creatinine clearance: P _interaction=0.7, P _time<0.0001, P _sex=0.07. HS indicates high salt; and NS, normal salt.