Figure 5. HS diet challenge increases renal outer medullary endothelin receptor expression in a sex‐dependent manner.

mRNA expression of cortical (A through D), outer medullary (E through H), and inner medullary (I through L) ET_A and ET_B receptors in male and female Sprague Dawley rats during the NS diet phase or on day 1 of the HS diet challenge (n=5–6 rats in each group). Gene expression values represent the fold change from corresponding NS levels. Statistical comparisons were performed by unpaired Student t test. P<0.05 vs corresponding NS values. ET_A indicates endothelin receptor subtype A; ET_B, endothelin receptor subtype B; HS, high salt; and NS, normal salt.