Table 1.
Sex Differences in Na+‐Regulatory Factors During Acclimation to an HS Diet Challenge
| Males (n=5–8) | Females (n=6–11) | ANOVA results | |||||
|---|---|---|---|---|---|---|---|
| Urinary excretion rate | NS | Day 1 HS | Day 5 HS | NS | Day 1 HS | Day 5 HS | |
| Endothelin‐1, pg/day per kg | 5.6±0.8 | 10.2±0.5* | 10.6±0.7* | 11.8±3.9 † | 14.6±2.0 | 14.9±2.3 |
P interaction=0.9 P diet=0.2 P sex=0.006 |
| NOx, µmol/day per kg | 22.5±1.0 | 24.6±1.8 | 7.7±0.7* | 20.1±3.5 | 32.7±4.7* | 7.8±0.7* |
P interaction=0.08 P diet<0.0001 P sex=0.5 |
| Aldosterone, µg/day per kg | 14.1±2.3 | 5.8±0.9* | 4.3±0.6* | 17.3±2.9 | 13.3±1.5 | 5.3±0.7* |
P interaction=0.4 P diet<0.0001 P sex=0.18 |
| Norepinephrine, µg/day per kg | 5.2±0.3 | 4.6±0.2 | 4.9±0.5 | 4.0±1.0 | 6.8±1.1 | 5.9±1.1 |
P interaction=0.1 P diet=0.4 P sex=0.4 |
Statistical comparisons were performed by repeated‐measures 2‐way ANOVA with Sidak’s post hoc test for multiple comparisons. HS, high salt; and NS, normal salt.
*
P<0.05 vs corresponding NS values.
†
P<0.05 vs corresponding male values.