Bioreductions on preparative scale^a.

Substrate	Enzyme (mg mL−1)	Product	Isolated yield (%)	d.r.
	pQR1445 (0.5)		95b	98 : 2
	pQR1907 (1)		95b	Syn only
	pQR1907 (2)		71b,c	Syn only
	pQR1907 (2)		90d	58 : 42
	pQR1907 (2)		90d	85 : 15
	pQR1907 (1)		94b	Syn only
	pQR1907 (4)		50d	—

^aSubstrate (5 mM for rac-16; 10 mM for S-5 and R-11 20 mM for S-8, S-11, rac-11, S-14), co-expressed ER/G6PDH (1–4 mg mL⁻¹), NADP⁺ (2.8 mM), G6PNa (100 mM), in Tris–HCl (50 mM) and DMSO (10%) at pH = 7.4, 30 °C, 300 rpm.

^bIsolated yield.

^cPurification by column chromatography.

^d2.5 mL scale. Quantification by NMR using an internal standard (1,3,5-trimethoxybenzene).