. 2019 Nov 12;9(63):36742–36750. doi: 10.1039/c9ra06651a

Semi quantitative scores of haematoxylin and eosin stained sections of subcutaneously implanted collagen scaffolds treated with salt.

Parameter	Scaffold	Mean ± SD
Parameter	Scaffold	Day 3	Day 14	Day 90
Capsule	CaCl₂	1.0 ± 0.5	2.8 ± 0.3	2.0 ± 0.5
	NaCl	0.3 ± 0.3	2.3 ± 0.4	1.7 ± 0.6
	Untreated	1.0 ± 0.7	2.5 ± 0.5	1.7 ± 1.3
Cellular influx	CaCl₂	0.0 ± 0.0^a	0.5 ± 0.5	0.7 ± 0.3^a
	NaCl	0.5 ± 0.0^a	0.8 ± 0.4	2.8 ± 0.3^a
	Untreated	0.5 ± 0.0^a	1.0 ± 0.5	1.7 ± 0.6^a
Granulocytes	CaCl₂	1.2 ± 0.6	0.1 ± 0.0	0.1 ± 0.0
	NaCl	0.5 ± 0.0	0.1 ± 0.0	0.1 ± 0.0
	Untreated	0.8 ± 0.4	0.4 ± 0.2	0.2 ± 0.2
Macrophages & giant cells	CaCl₂	0.1 ± 0.0	1.2 ± 0.3	0.7 ± 0.3
	NaCl	0.1 ± 0.0	1.0 ± 0.0	1.7 ± 0.6
	Untreated	0.3 ± 0.3	1.2 ± 0.3	1.3 ± 0.3
Lymphocytes	CaCl₂	0.2 ± 0.2	0.1 ± 0.0	0.4 ± 0.2
	NaCl	0.1 ± 0.0	0.1 ± 0.0	0.2 ± 0.2
	Untreated	0.1 ± 0.0	0.1 ± 0.0	0.4 ± 0.2
Blood vessels	CaCl₂	0.0 ± 0.0	0.0 ± 0.1	0.2 ± 0.2^a
	NaCl	0.0 ± 0.0	0.1 ± 0.0	2.5 ± 0.5^a
	Untreated	0.0 ± 0.0	0.5 ± 0.5	1.0 ± 0.5^a
Degradation	CaCl₂	0.0 ± 0.0	0.1 ± 0.0	0.4 ± 0.2^a
	NaCl	0.0 ± 0.0	0.5 ± 0.0	2.3 ± 1.2^a
	Untreated	0.0 ± 0.0	0.4 ± 0.2	1.2 ± 0.3^a

Significant differences by Kruskal Wallis test between scaffolds at one time point. Cellular influx day 3 p = 0.030; cellular influx day 90 p = 0.029; blood vessels day 90 p = 0.031; degradation day 90 p = 0.044.