Table 1.
Summary of Meta‐Analysis Results
| Outcomes | Studies | Sample size | Effect size, aOR (95% CI) | P value | I 2, % |
|---|---|---|---|---|---|
| Survival to discharge, 30 d with good neurological outcome | |||||
| Adjusted analyses | |||||
| CACs only | 5 | 58 835 | 1.85 (1.52–2.26) | <0.00001* | 75 |
| CACs+high‐volume centers | 8 | 61 733 | 1.50 (1.18–1.91) | 0.0008* | 84 |
| CACs+improved‐care centers | 11 | 65 292 | 2.13 (1.75–2.59) | <0.00001* | 73 |
| Unadjusted analyses | |||||
| CACs only | 7 | 59 239 | 2.27 (1.58–3.25) | <0.00001* | 90 |
| CACs+high‐volume centers | 10 | 64 512 | 1.82 (1.35–2.46) | <0.00001* | 92 |
| CACs+improved‐care centers | 14 | 64 936 | 2.16 (1.67–2.81) | <0.00001* | 84 |
| Subgroup analyses | |||||
| Shockable/nonshockable | 5 | 9129 | … | 0.006* | … |
| Prehospital ROSC/no ROSC | 5 | 14 116 | … | 0.09 | … |
| Survival to discharge, 30 d | |||||
| Adjusted analyses | |||||
| CACs only | 7 | 25 895 | 1.92 (1.59–2.32) | <0.00001* | 71 |
| CACs+high‐volume centers | 9 | 31 406 | 1.74 (1.38–2.18) | <0.00001* | 85 |
| CACs+improved‐care centers | 12 | 27 762 | 1.97 (1.71–2.26) | <0.00001* | 54 |
| Unadjusted analyses | |||||
| CACs only | 11 | 42 323 | 2.14 (1.75–2.61) | <0.00001* | 89 |
| CACs+high‐volume centers | 18 | 84 359 | 1.98 (1.63–2.40) | <0.00001* | 93 |
| CACs+improved‐care centers | 19 | 47 072 | 2.04 (1.72–2.43) | <0.00001* | 84 |
| Subgroup analyses | |||||
| Shockable/nonshockable | 7 | 11 207 | … | 0.73 | … |
| Prehospital ROSC/no ROSC | 9 | 53 592 | … | 0.005* | … |
aOR indicates adjusted odds ratio; CACs, cardiac arrest centers; and ROSC, return of spontaneous circulation.
*
P < 0.05.