. 2001 Oct;45(10):2916–2921. doi: 10.1128/AAC.45.10.2916-2921.2001

TABLE 1.

Pharmacodynamic parameters associated with S. pneumoniae strain susceptibilities and the pharmacokinetics modeled

Strain	MIC (mg/liter)	Pharmacodynamic parameters^a
		AUC/MIC			C_max/MIC			T > MIC
		640 × 1	320 × 2	160 × 4	640 × 1	320 × 2	160 × 4	640 × 1	320 × 2	160 × 4
18964	0.016	1,081	1,081	1,219	131	68	42	100	100	100
18330	0.06	288	288	325	35	18	11	80	100	100
18327	0.10	173	173	195	21	11	6.8	54	84	100
18907	0.16	108	108	122	13	6.8	4.2	47	61	94
18329	0.24	72	72	81	8.8	4.5	2.8	38	42	77

For each parameter, values are given for three dosing regimens (given as dose in milligrams × the number of times administered in a 48-h period).