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. 2021 Dec 20;11(1):e023277. doi: 10.1161/JAHA.121.023277

Figure 2. Independent associations between genetic scores for IL‐6 signaling and LDL‐C with risk of cardiovascular disease.

Figure 2

A, Nonscaled associations. B, Associations scaled to 38.67 mg/dL (1 mmol/L) decrement in LDL‐C levels and 0.50 log(mg/L) decrement in log‐transformed C‐reactive protein levels. The upper panels of (A and B) represent associations from the 2×2 analysis dividing participants into 4 groups according to the median genetic IL‐6 and LDL‐C scores. The lower panels of (A and B) represent associations from an analysis where the 2 genetic scores were included on a continuous scale as well as the interaction between the 2 scores. The results are derived from logistic regression models adjusted for age, sex, the first 10 principal components of population structure, and the genotyping array. IL6 indicates interleukin‐6; LDL‐C, low‐density lipoprotein cholesterol; and OR, odds ratio.