Table 2.

ACEi/ARB Use and Biomarkers of Thrombo‐Inflammation

	Biomarker, standardized β, P value
	SuPAR	C‐reactive protein	Lactate dehydrogenase	Interleukin‐6	Procalcitonin	Ferritin	D‐dimer
ACEi/ARB use	−0.080, P=0.001*	−0.055, P=0.038*	−0.008, P=0.76	−0.032, P=0.45	0.003, P=0.93	−0.001, P=0.96	−0.044, P=0.11
Age	−0.063, P=0.030	−0.030, P=0.34	−0.098, P=0.003	−0.074, P=0.15	0.010, P=0.76	−0.032, P=0.32	−0.015, P=0.64
Male sex	0.001, P=0.95	−0.030, P=0.23	−0.084, P=0.001	−0.056, P=0.17	−0.007, P=0.78	−0.116, P<0.001	−0.027, P=0.31
Body‐mass index	0.078, P=0.002	0.065, P=0.015	0.081, P=0.004	−0.004, P=0.94	−0.025, P=0.37	0.015, P=0.57	−0.022, P=0.43
Black race	−0.021, P=0.38	0.049, P=0.05	0.099, P<0.001	−0.026, P=0.52	0.012, P=0.66	0.077, P=0.003	−0.034, P=0.20
Diabetes	0.046, P=0.07	0.033, P=0.23	−0.037, P=0.20	0.044, P=0.33	−0.015, P=0.60	0.006, P=0.83	0.035, P=0.22
Hypertension	0.014, P=0.61	−0.009, P=0.76	−0.051, P=0.11	0.044, P=0.37	−0.046, P=0.15	−0.026, P=0.40	0.039, P=0.22
Coronary artery disease	0.023, P=0.36	0.001, P=0.98	−0.028, P=0.32	−0.032, P=0.47	−0.008, P=0.79	−0.042, P=0.13	−0.025, P=0.37
Heart failure	0.049, P=0.049	−0.026, P=0.32	0.009, P=0.75	0.003, P=0.94	−0.011, P=0.70	−0.045, P=0.10	−0.01, P=0.71
Admission estimated glomerular filtration rate	−0.325, P<0.001	−0.080, P=0.010	−0.117, P<0.001	−0.048, P=0.33	−0.054, P=0.10	−0.135, P<0.001	−0.039, P=0.22

ACEi/ARB indicates angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker; and SuPAR, soluble urokinase plasminogen activator receptor.

^*Statistically significant P values at α=0.05 for associations between ACEi/ARB and biomarkers.