Table 3.
Multivariable Analysis of the Association Between In‐Hospital ACEi/ARB Use and Outcomes
| Variables | Death, mechanical ventilation, or dialysis (n=480) | |||
|---|---|---|---|---|
| Odds ratio* (95% CI) | P value | Hazard ratio † (95% CI) | P value | |
| In‐hospital ACEi/ARB use | 0.49 (0.36–0.66) | <0.001 ‡ | 0.48 (0.36–0.65) | <0.001 ‡ |
| Age, per 10 y | 1.00 (0.91–1.08) | 0.90 | 0.94 (0.88–1.00) | 0.06 |
| Male sex | 1.43 (1.14–1.80) | 0.002 ‡ | 1.21 (1.00–1.46) | 0.046 ‡ |
| Black race | 1.29 (0.98–1.71) | 0.07 | 1.27 (1.02–1.59) | 0.030 ‡ |
| Body mass index, per 5 kg/m2 | 1.13 (1.06–1.21) | <0.001 ‡ | 1.07 (1.03–1.11) | <0.001 ‡ |
| Diabetes | 1.12 (0.86–1.46) | 0.41 | 1.08 (0.88–1.33) | 0.46 |
| Hypertension | 1.22 (0.93–1.61) | 0.15 | 1.24 (1.00–1.55) | 0.05 |
| Coronary artery disease | 0.99 (0.69–1.41) | 0.93 | 1.12 (0.84–1.48) | 0.45 |
| Congestive heart failure | 0.96 (0.66–1.39) | 0.82 | 0.83 (0.62–1.11) | 0.21 |
| Admission eGFR, per 5 mL/min higher | 0.95 (0.93–0.98) | <0.001 ‡ | 0.95 (0.94–0.97) | <0.001 ‡ |
ACEi/ARB indicates angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker; and eGFR, estimated glomerular filtration rate.
Based on binary logistic regression model adjusted for age, sex, race, body mass index, diabetes, hypertension, coronary artery disease, congestive heart failure, and admission eGFR.
Based on time‐dependent Cox proportional hazards model adjusted for age, sex, race, body mass index, diabetes, hypertension, coronary artery disease, congestive heart failure, and admission eGFR.
Based on time‐dependent Cox proportional hazards model adjusted for age, sex, race, body mass index, diabetes mellitus, hypertension, coronary artery disease, congestive heart failure, and admission eGFR.