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. 2021 Dec 7;10(24):e022332. doi: 10.1161/JAHA.121.022332

Figure 7. Primary cilia are deficient within human peripapillary fibrotic regions in patients with mitral valve prolapse.

Figure 7

A and B, Within apex myocardium of patients with mitral valve repair, primary cilia axonemes (pink) are evident (arrows). Within fibrotic zones of the peripapillary regions, axonemes are either absent or deficient as quantified by immunohistochemistry and pixel intensity (C). Western analyses of human cardiac fibroblasts plated on matrices of increasing stiffness showed a significant downregulation of ADP ribosylation factor like GTPase 13B (ARL13B) protein, a surrogate for primary ciliogenesis (D and E). Scale bars sizes are denoted in panels.