Table 3.
Outcomes Stratified by Quintiles of NT‐proBNP
|
Outcomes n (%) or median (Q1 − Q3) |
Quintile 1 NT‐proBNP (10–55 pg/mL) (n=935) |
Quintile 2 NT‐proBNP (55–175 pg/mL) (n=935) |
Quintile 3 NT‐proBNP (175–545 pg/mL) (n=935) |
Quintile 4 NT‐proBNP (545–2385 pg/mL) (n=935) |
Quintile 5 NT‐proBNP (>2385 pg/mL) (n=935) |
|---|---|---|---|---|---|
| In‐hospital mortality | 66 (7.1) | 114 (12.2) | 192 (20.5) | 289 (30.9) | 376 (40.2) |
| MACEs | 83 (8.9) | 155 (16.6) | 224 (24.0) | 339 (36.3) | 460 (49.2) |
| Intubation | 125 (13.4) | 197 (21.1) | 237 (25.3) | 266 (28.4) | 287 (30.7) |
| ICU admission | 213 (22.9) | 316 (33.8) | 373 (39.9) | 392 (41.9) | 432 (46.2) |
| Shock | 49 (5.2) | 89 (9.5) | 126 (13.5) | 160 (17.1) | 184 (19.7) |
| Cardiac arrest | 32 (3.5) | 55 (5.9)** | 48 (5.1)* | 83 (8.9) | 118 (12.6) |
| New acute heart failure | 1.4% (13) | 2.4% (22)* | 2.5% (23)* | 3.5% (33)** | 6.5% (61) |
| Time to death, d | 12.0 (6.0–20.8) | 9.0 (4.0–14.3)* | 10.0 (6.0–17.0)* | 8.0 (4.0–15.0)** | 6.0 (3.0–13.7) |
ICU indicates intensive care unit; MACEs, major adverse cardiac events as defined as death, acute myocardial infarction, stroke, shock, new onset heart failure, or myocarditis; and NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide. Quintiles formed from whole NT‐proBNP cohort (n=4675). All comparisons to the referent quintile 1 were highly significant (P<0.001) with the exception of those marked as *P=NS, **P<0.05.