Table 4.

Change in Risk Predictive Metrics by Incorporating GDF‐15 to the Model Including NT‐proBNP and hs‐TnT

	c‐statistics (95% CI)	Category‐free NRI (95% CI)	IDI (95% CI)
All‐cause death
Model 2	0.787 (0.748–0.827)
Model 2+log GDF‐15	0.802 (0.764–0.840)*	0.180 (0.069–0.276) †	0.028 (0.010–0.055) ‡
Stroke event
Model 2	0.811 (0.766–0.857)
Model 2+log GDF‐15	0.817 (0.773–0.862)*	0.134 (−0.080–0.256)	0.006 (0.000–0.027)*
Cardiac event
Model 2	0.789 (0.749–0.829)
Model 2+log GDF‐15	0.789 (0.749–0.829)*	−0.005 (0.068–0.114)	0.000 (−0.001–0.005)

Model 2 was the model incorporating log NT‐proBNP and log hs‐TnT to model 1, which is described in Table 3. GDF‐15, growth differentiation factor‐15; hs‐TnT, high sensitive troponin T; IDI, integrated discrimination improvement; NRI, net reclassification improvement; and NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.

^* P<0.05.

^† P<0.01.

^‡ P<0.001.