Figure 2. Categories of aldosterone and renin phenotype at baseline and long‐term risk of cardiovascular diseases, according to classifications of blood pressure in the whole group of FOS (Framingham Offspring Study).

Serum aldosterone concentration (SAC) ≥10 ng dL⁻¹ was suspected as aldosteronism; plasma renin concentration (PRC) ≤15 mU/L was considered as low‐renin status; subjects with PRC ≤15 mU/L and SAC ≥10 ng dL⁻¹ were classified as renin‐independent aldosteronism, and subjects with PRC >15 mU/L and SAC ≥10 ng dL⁻¹ were classified as renin‐dependent aldosteronism. Baseline blood pressure was stratified on the basis of definitions for normotension, prehypertension, and stages 1–3 of hypertension. For SAC, 1 ng/dL = 27 pmol/L. All of these effects are based on the multivariate model, which adjusted for age, sex, body mass index, current smoking status, alcohol consumption, total cholesterol, presence or absence of diabetes, antihypertensive medication use, and sodium status. Columns colored in red indicate that the false discovery rate is <0.05. CVD indicates cardiovascular disease; DBP, diastolic blood pressure; and SBP, systolic blood pressure.