Table 4.
Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate (Versus Placebo) on Magnesium Parameters
|
Magnesium citrate (n=46) |
Magnesium oxide (n=46) |
Magnesium sulfate (n=46) |
Placebo (n=26) |
|
|---|---|---|---|---|
| Plasma magnesium | ||||
| 2‐wk | ||||
| Mean, mmol/L | 0.88±0.06 | 0.86±0.05 | 0.86±0.08 | 0.85±0.07 |
| Difference vs placebo | 0.03 (0.01–0.05)** | 0.03 (0.01–0.05)* | 0.02 (0.00–0.04) | … |
| 12‐wk | ||||
| Mean, mmol/L | 0.87±0.05 | 0.86±0.04 | 0.86±0.10 | 0.85±0.06 |
| Difference vs placebo | 0.03 (0.01–0.05)* | 0.04 (0.02–0.06)** | 0.03 (0.01–0.05)* | … |
| 24‐wk | ||||
| Mean, mmol/L | 0.88±0.06 | 0.86±0.05 | 0.85±0.08 | 0.85±0.06 |
| Difference vs placebo | 0.04 (0.02–0.06)** | 0.03 (0.01–0.05)** | 0.02 (0.00–0.04) | … |
| Urinary magnesium | ||||
| 2‐wk | ||||
| Mean, mmol/24‐h | 7.24±2.11 | 7.06±1.86 | 6.80±2.12 | 5.41±1.97 |
| Difference vs placebo | 2.29 (1.41–3.17)*** | 1.93 (1.05–2.80)*** | 1.82 (0.95–2.70)*** | … |
| 12‐wk | ||||
| Mean, mmol/24‐h | 7.60±1.91 | 7.03±2.01 | 6.61±2.35 | 5.32±2.11 |
| Difference vs placebo | 2.71 (1.83–3.59)*** | 2.14 (1.26–3.02)*** | 1.75 (0.87–2.63)*** | … |
| 24‐wk | ||||
| Mean, mmol/24‐h | 7.79±1.92 | 7.07±1.88 | 6.62±2.23 | 5.11±1.83 |
| Difference vs placebo | 3.12 (2.23–4.01)*** | 2.38 (1.50–3.26)*** | 2.07 (1.19–2.96)*** | … |
Values are mean±SD. Adjusted mean differences (95% CIs) were obtained from linear mixed‐effect models with age, sex, baseline value of the outcome of interest, time, intervention, and the interaction time×intervention as fixed effects.
*
P<0.05.
**
P<0.01.
***
P<0.001 (2‐sided P values).