Table 2.

Dose‐Response Association Between the Amount of Physical Activity and LoRI Mortality and Hospitalization Rates

Amount of physical activity, MET min/wk	No. of events	Event rate, n/10 000 person‐years	Age‐ and sex‐adjusted		Multivariate‐adjusted*		Multivariate‐adjusted †
			HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Mortality
0	3751	15.4	1 (Reference)	…	1 (Reference)	…	1 (Reference)	…
<500	1968	8.5	0.70 (0.67–0.74)	<0.001	0.72 (0.68–0.76)	<0.001	0.74 (0.70–0.78)	<0.001
500–999	1707	7.8	0.63 (0.59–0.66)	<0.001	0.65 (0.61–0.68)	<0.001	0.66 (0.62–0.70)	<0.001
1000–1499	447	5.1	0.48 (0.43–0.53)	<0.001	0.50 (0.45–0.55)	<0.001	0.52 (0.47–0.57)	<0.001
≥1500	364	6.6	0.51 (0.45–0.56)	<0.001	0.53 (0.47–0.59)	<0.001	0.54 (0.49–0.60)	<0.001
Hospitalization
0	44 148	172.8	1 (Reference)	…	1 (Reference)	…	1 (Reference)	…
<500	29 992	122.1	0.81 (0.80–0.83)	<0.001	0.83 (0.82–0.84)	<0.001	0.84 (0.83–0.85)	<0.001
500–999	26 660	113.7	0.74 (0.73–9.76)	<0.001	0.77 (0.75–0.78)	<0.001	0.77 (0.76–0.79)	<0.001
1000–1499	9153	96.6	0.68 (0.66–0.69)	<0.001	0.70 (0.69–0.72)	<0.001	0.72 (0.70–0.73)	<0.001
≥1500	6328	106.7	0.68 (0.66–0.69)	<0.001	0.70 (0.68–0.72)	<0.001	0.71 (0.69–0.73)	<0.001

HR indicates hazard ratio; LoRI, lower respiratory tract infection; and MET, metabolic equivalents of task.

^*HRs were calculated by Cox models, after adjusting for age at baseline, sex, smoking status, alcohol consumption frequency, and household income.

^† HRs were calculated by Cox models, after adjusting for age at baseline, sex, smoking status, alcohol consumption frequency, household income, blood pressure status, fasting glucose status, body mass index, prevalent chronic obstructive pulmonary disease, and history of admission attributable to LoRI.