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. 2022 Mar 5;11(6):e023678. doi: 10.1161/JAHA.121.023678

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Representative echocardiogram of coronary artery endothelial cells from floxed TRPC1 (TRPC1^fl/fl) and TRPC1_EC ^‐/‐ mice at 3 days and 28 days post‐myocardial infarction. B, Change in ejection fraction from 3 days to 28 days after left anterior descending artery ligation in TRPC1^fl/fl and TRPC1_EC ^‐/‐ mice. C, Quantitative analysis of fractional shortening. D, Quantitative analysis of systolic left ventricular internal dimensions. E, Quantitative analysis of diastolic left ventricular internal dimensions. (n=4; ^** P<0.01 vs TRPC1^fl/fl, unpaired t test). F, Infarct size in TRPC1^fl/fl and TRPC1_EC ^‐/‐ groups measured by triphenyltetrazolium chloride staining (scale bar, 0.5 cm). G, Statistics of the relative infarct size (n=3; ^* P<0.05 vs TRPC1^fl/fl, unpaired t test). H, Representative confocal laser scanning microscope images showing capillary density in hearts from TRPC1^fl/fl and TRPC1_EC ^‐/‐ myocardial infarction‐model mice (red, cardiac CD31; blue, DAPI; scale bar, 20 μm). I, Quantitation of capillary density in remote zone of left ventricle from TRPC1^fl/fl and TRPC1_EC ^‐/‐ myocardial infarction‐model mice (n=3; ^* P<0.05 vs TRPC1^fl/fl, unpaired t test). The data are presented as mean ± SD. DAPI indicates 4’,6‐diamidino‐2‐phenylindole; EF, ejection fraction; FS, fractional shortening; LVIDd, diastolic left ventricular internal dimensions; LVIDs, systolic left ventricular internal dimensions; MI, myocardial infarction; TRPC1_EC ^‐/‐, endothelial cell‐specific TRPC1 channel knockout; TRPC1^fl/fl, coronary artery endothelial cells from floxed TRPC1; and siTRPC, TRPC siRNA.