Table 3.
Multivariable Linear Regression for the Associations of Total Life’s Simple 7 Score With Test‐Specific and Global Cognition*
|
Quintile 1 Total score<6 (n=609) |
Quintile 2 Total score=6 (n=512) |
Quintile 3 Total score=7 (n=473) |
Quintile 4 Total score=8 (n=425) |
Quintile 5 Total score>8 (n=566) |
Continuous score |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| β (95% CI) | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | |
| Global cognition | Reference | 0.15 (−0.01 to 0.31) | 0.0681 | 0.15 (0.04 to 0.27) † | 0.0108 † | 0.12 (−0.02 to 0.27) | 0.0969 | 0.29 (0.15 to 0.43) † | 0.0001 † | 0.05 (0.02 to 0.07) † | 0.0002 † |
| DSST | Reference | 0.10 (−0.02 to 0.23) | 0.1027 | 0.16 (0.02 to 0.30) † | 0.0255 † | 0.26 (0.12 to 0.40) † | 0.0007 † | 0.29 (0.16 to 0.42) † | <0.0001 † | 0.05 (0.03 to 0.07) † | <0.0001 |
| CERAD‐WL delayed memory | Reference | 0.11 (−0.07 to 0.28) | 0.2190 | 0.09 (−0.05 to 0.23) | 0.2196 | ‐0.03 (−0.20 to 0.14) | 0.7266 | 0.13 (−0.02 to 0.28) | 0.0862 | 0.02 (−0.01 to 0.04) | 0.1254 |
| CERAD‐WL immediate memory | Reference | 0.15 (−0.02 to 0.31) | 0.0757 | 0.04 (−0.07 to 0.14) | 0.4668 | 0.02 (−0.15 to 0.19) | 0.8102 | 0.16 (0.03 to 0.28) † | 0.0201 † | 0.03 (0.004 to 0.05) † | 0.0218 † |
| AFT | Reference | 0.09 (−0.08 to 0.26) | 0.2785 | 0.16 (−0.01 to 0.32) | 0.0595 | 0.08 (−0.07 to 0.24) | 0.2798 | 0.27 (0.13 to 0.41) † | 0.0006 † | 0.05 (0.02 to 0.07) † | 0.0004 † |
AFT indicates Animal Fluency Test; CERAD‐WL, Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subtest; and DSST, Digit Symbol Substitution Test.
*
Models were adjusted for age, sex, race and ethnicity, education, other Life’s Simple 7 components, coronary heart disease.
†
P<0.05.