Table 2.

Relative Risk of All‐Cause Mortality, According to AT/ET

Variable	All‐cause mortality
Outcome under conservative management		HR (95% CI)	P value
	Univariate analysis
	AT/ET per increment of 0.01	1.09 (1.04–1.16)	<0.001
	AT/ET ≤0.35	Reference
	AT/ET >0.35	2.44 (1.39–4.29)	<0.001
	Multivariable model (n=230)*
	AT/ET per increment of 0.01	1.11 (1.04–1.18)	0.002
	AT/ET ≤0.35	Reference
	AT/ET >0.35	3.29 (1.70–6.39)	<0.001
Outcome under medical and/or surgical management		Adjusted HR (95% CI)	P value
	Univariate analysis
	AT/ET per increment of 0.01	1.06 (1.01–1.11)	0.018
	AT/ET ≤0.35	Reference
	AT/ET >0.35	1.89 (1.16–3.08)	0.010
	Multivariable model without AVR (n=347)*
	AT/ET per increment of 0.01	1.08 (1.02–1.14)	0.009
	AT/ET ≤0.35	Reference
	AT/ET >0.35	2.34 (1.36–4.03)	0.002
	Multivariable model with AVR (n=347) †
	AT/ET per increment of 0.01	1.09 (1.03–1.15)	0.004
	AT/ET ≤0.35	Reference
	AT/ET >0.35	2.54 (1.47–4.37)	<0.001

AT/ET indicates ratio of acceleration time/ejection time; AVR, aortic valve replacement; and HR, hazard ratio.

^*Multivariable model is adjusted for age, sex, systolic blood pressure, Charlson comorbidity index (without including age), history of atrial fibrillation, peak aortic jet velocity, left ventricular stroke volume index, and left ventricular ejection fraction.

^† Model is adjusted for covariates included in the model without AVR and AVR as time‐dependent covariate.