Table 3.
Relationships Between Multiple Proteins at Age 70 Years and Incident MI in ULSAM
| Variable | Gene name | Age‐adjusted | Adjusted for traditional cardiovascular risk factors | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI lower | 95%CI higher | P value | HR | 95% CI lower | 95% CI higher | P value | ||
| WAP 4‐disulfide core domain protein 2 | WFDC2 | 1.66 | 1.37 | 2 | 1.67E‐07 | 1.6 | 1.3 | 1.96 | 6.65E‐06 |
| Growth differentiation factor 15 | GDF15 | 1.63 | 1.35 | 1.97 | 3.33E‐07 | 1.51 | 1.23 | 1.84 | 6.12E‐05 |
| Tumor necrosis factor receptor superfamily member 10B | TRAILR2 | 1.55 | 1.28 | 1.86 | 4.42E‐06 | 1.51 | 1.24 | 1.84 | 4.45E‐05 |
| Retinoic acid receptor responder protein 2 | RARRES2 | 1.52 | 1.27 | 1.83 | 6.45E‐06 | 1.51 | 1.24 | 1.85 | 5.84E‐05 |
| Tumor necrosis factor receptor superfamily member 1A | TNFR1 | 1.52 | 1.26 | 1.83 | 1.35E‐05 | 1.51 | 1.24 | 1.84 | 4.21E‐05 |
| Macrophage metalloelastase | MMP12 | 1.48 | 1.23 | 1.78 | 2.54E‐05 | 1.36 | 1.11 | 1.67 | 3.00E‐03 |
| Tumor necrosis factor receptor superfamily member 19 | TNFRSF19 | 1.47 | 1.23 | 1.77 | 3.21E‐05 | 1.52 | 1.25 | 1.85 | 2.43E‐05 |
| Trefoil factor 3 | TFF3 | 1.46 | 1.22 | 1.75 | 3.64E‐05 | 1.46 | 1.2 | 1.77 | 1.50E‐04 |
| Inactive tyrosine‐protein kinase 7 | PTK7 | 1.44 | 1.2 | 1.73 | 7.78E‐05 | 1.42 | 1.18 | 1.71 | 2.60E‐04 |
| Macrophage receptor MARCO | MARCO | 1.43 | 1.2 | 1.71 | 9.85E‐05 | 1.39 | 1.15 | 1.68 | 6.06E‐04 |
| CD27 antigen | CD27 | 1.43 | 1.19 | 1.73 | 1.72E‐04 | 1.42 | 1.16 | 1.72 | 5.56E‐04 |
| Urokinase plasminogen activator surface receptor | UPAR | 1.4 | 1.17 | 1.67 | 1.72E‐04 | 1.32 | 1.09 | 1.59 | 3.90E‐03 |
| Alpha‐1‐microglobulin | AMBP | 1.41 | 1.17 | 1.69 | 2.24E‐04 | 1.38 | 1.14 | 1.68 | 1.12E‐03 |
| Hepatitis A virus cellular receptor 1 | KIM1 | 1.42 | 1.18 | 1.71 | 2.59E‐04 | 1.27 | 1.03 | 1.55 | 2.31E‐02 |
| Tumor necrosis factor receptor superfamily member 4 | TNFRSF4 | 1.41 | 1.17 | 1.7 | 3.12E‐04 | 1.39 | 1.15 | 1.69 | 8.88E‐04 |
| Inhibin beta C chain | INHBC | 1.39 | 1.16 | 1.66 | 3.17E‐04 | 1.35 | 1.11 | 1.64 | 2.30E‐03 |
| Tumor necrosis factor receptor superfamily member 1B | TNFR2 | 1.4 | 1.16 | 1.68 | 3.31E‐04 | 1.41 | 1.16 | 1.71 | 4.76E‐04 |
| Tumor necrosis factor receptor superfamily member 19L | RELT | 1.4 | 1.16 | 1.68 | 3.65E‐04 | 1.38 | 1.14 | 1.67 | 1.11E‐03 |
| CCN family member 4 | WISP1 | 1.37 | 1.15 | 1.64 | 4.60E‐04 | 1.31 | 1.09 | 1.58 | 4.86E‐03 |
| C‐X‐C motif chemokine 16 | CXCL16 | 1.38 | 1.15 | 1.65 | 4.83E‐04 | 1.3 | 1.08 | 1.57 | 5.66E‐03 |
| Corticotropin‐releasing factor‐binding protein | CRHBP | 1.37 | 1.15 | 1.64 | 5.03E‐04 | 1.3 | 1.08 | 1.57 | 6.70E‐03 |
| Cathepsin Z | CTSZ | 1.37 | 1.15 | 1.63 | 5.19E‐04 | 1.38 | 1.14 | 1.68 | 8.88E‐04 |
| Receptor tyrosine‐protein kinase erbB‐3 | ERBB3 | 1.36 | 1.14 | 1.62 | 5.68E‐04 | 1.28 | 1.06 | 1.55 | 9.96E‐03 |
| Tumor necrosis factor receptor superfamily member 10A | TNFRSF10A | 1.38 | 1.15 | 1.66 | 5.73E‐04 | 1.38 | 1.14 | 1.66 | 1.07E‐03 |
| C‐type lectin domain family 5 member A | CLEC5A | 1.37 | 1.15 | 1.65 | 5.95E‐04 | 1.31 | 1.07 | 1.6 | 8.00E‐03 |
| Leukocyte‐associated immunoglobulin‐like receptor 1 | LAIR1 | 1.37 | 1.14 | 1.64 | 7.32E‐04 | 1.4 | 1.16 | 1.7 | 5.31E‐04 |
| Protein S100‐A11 | S100A11 | 1.35 | 1.13 | 1.61 | 7.44E‐04 | 1.26 | 1.04 | 1.52 | 1.57E‐02 |
| Transmembrane glycoprotein NMB | GPNMB | 1.35 | 1.13 | 1.61 | 8.84E‐04 | 1.27 | 1.06 | 1.53 | 9.58E‐03 |
| Collectin‐12 | COLEC12 | 1.36 | 1.13 | 1.63 | 9.13E‐04 | 1.4 | 1.16 | 1.69 | 5.06E‐04 |
| Metalloproteinase inhibitor 4 | TIMP4 | 1.36 | 1.13 | 1.62 | 9.90E‐04 | 1.43 | 1.17 | 1.74 | 3.47E‐04 |
| Triggering receptor expressed on myeloid cells 1 | TREM1 | 1.36 | 1.13 | 1.63 | 1.17E‐03 | 1.33 | 1.09 | 1.61 | 4.08E‐03 |
| Ephrin type‐A receptor 2 | EPHA2 | 1.37 | 1.13 | 1.65 | 1.18E‐03 | 1.42 | 1.16 | 1.74 | 5.87E‐04 |
| Cystatin‐B | CSTB | 1.33 | 1.12 | 1.59 | 1.27E‐03 | 1.32 | 1.09 | 1.6 | 3.97E‐03 |
| Metalloproteinase inhibitor 1 | TIMP1 | 1.34 | 1.12 | 1.6 | 1.32E‐03 | 1.22 | 1.01 | 1.47 | 3.79E‐02 |
| Tumor necrosis factor receptor superfamily member 11B | OPG | 1.34 | 1.12 | 1.6 | 1.35E‐03 | 1.26 | 1.04 | 1.53 | 1.78E‐02 |
| C‐C motif chemokine 7 | MCP3 | 1.32 | 1.11 | 1.57 | 1.48E‐03 | 1.23 | 1.01 | 1.48 | 3.63E‐02 |
| Tumor necrosis factor ligand superfamily member 14 | TNFSF14 | 1.33 | 1.12 | 1.6 | 1.60E‐03 | 1.33 | 1.1 | 1.6 | 3.64E‐03 |
| Tumor necrosis factor receptor superfamily member 14 | TNFRSF14 | 1.33 | 1.12 | 1.6 | 1.60E‐03 | 1.33 | 1.1 | 1.6 | 3.64E‐03 |
| C‐X‐C motif chemokine 17 | CXL17 | 1.34 | 1.12 | 1.6 | 1.65E‐03 | 1.25 | 1.02 | 1.54 | 3.22E‐02 |
| CUB domain‐containing protein 1 | CDCP1 | 1.32 | 1.11 | 1.58 | 1.85E‐03 | 1.27 | 1.06 | 1.53 | 1.01E‐02 |
| Nectin‐2 | NECTIN2 | 1.34 | 1.11 | 1.61 | 1.96E‐03 | 1.33 | 1.09 | 1.62 | 5.16E‐03 |
| Carbonic anhydrase 6 | CA6 | 0.76 | 0.64 | 0.9 | 2.06E‐03 | 0.76 | 0.63 | 0.92 | 4.67E‐03 |
| Osteoclast‐associated immunoglobulin‐like receptor | hOSCAR | 1.33 | 1.11 | 1.59 | 2.12E‐03 | 1.32 | 1.09 | 1.59 | 4.67E‐03 |
| Tumor necrosis factor receptor superfamily member 6 | FAS | 1.33 | 1.11 | 1.59 | 2.20E‐03 | 1.26 | 1.04 | 1.53 | 1.84E‐02 |
| Proprotein convertase subtilisin/kexin type 9 | PCSK9 | 1.32 | 1.1 | 1.57 | 2.27E‐03 | 1.22 | 1.01 | 1.48 | 3.47E‐02 |
| CD99 antigen‐like protein 2 | CD99L2 | 1.32 | 1.1 | 1.57 | 2.29E‐03 | 1.32 | 1.1 | 1.59 | 3.38E‐03 |
| Spondin‐2 | SPON2 | 1.33 | 1.11 | 1.61 | 2.31E‐03 | 1.31 | 1.08 | 1.59 | 6.84E‐03 |
| Follistatin‐related protein 3 | FSTL3 | 1.33 | 1.11 | 1.61 | 2.38E‐03 | 1.34 | 1.1 | 1.63 | 3.97E‐03 |
| Glycoprotein Xg | XG | 1.32 | 1.1 | 1.58 | 2.41E‐03 | 1.37 | 1.13 | 1.66 | 1.16E‐03 |
| Hepatitis A virus cellular receptor 2 | HAVCR2 | 1.33 | 1.11 | 1.6 | 2.61E‐03 | 1.33 | 1.1 | 1.62 | 4.04E‐03 |
| Desmocollin‐2 | DSC2 | 1.32 | 1.1 | 1.58 | 2.62E‐03 | 1.37 | 1.13 | 1.66 | 1.15E‐03 |
| Cystatin‐C | CST3 | 1.32 | 1.1 | 1.59 | 2.93E‐03 | 1.24 | 1.02 | 1.5 | 2.77E‐02 |
| Nectin‐4 | PVRL4 | 1.31 | 1.09 | 1.57 | 3.57E‐03 | 1.33 | 1.09 | 1.61 | 4.11E‐03 |
Only proteins with a false discovery rate <0.05 for age‐adjusted P value and multiadjusted P value <0.05 are shown. HR indicates hazard ratio; MARCO, macrophage receptor with collagenous structure; MI, myocardial infarction; and ULSAM, Uppsala Longitudinal Study of Adult Men.