Table 3.

Subgroup Analyses for Risk of Cardiovascular Disease According to Avocado Intake^*

	Pooled adjusted HR (95% CI)	P value for Interaction
Sex
Women, n=7613 †	0.89 (0.73–1.08)	0.17
Men, n=6661	0.75 (0.63–0.88)
Age, y
<65, n=3496	0.94 (0.71–1.25)	0.19
≥65, n=10 778	0.79 (0.69–0.91)
BMI, kg/m2
<25, n=7352	0.80 (0.68–0.94)	0.86
≥25, n=6922	0.83 (0.68–1.01)
Ancestry
Mediterranean and other Caucasian, n=12 728	0.81 (0.71–0.92)	0.14
All other, including Hispanic, n=1546	0.68 (0.43–1.07)
Family history of myocardial infarction
No, n=8242	0.75 (0.64–0.88)	0.37
Yes, n=6032	0.91 (0.75–1.11)
AHEI
Below median, n=7547	0.86 (0.69–1.06)	0.32
Above median, n=6727	0.80 (0.69–0.94)
Total fruit intake
Below median, n=6471	0.78 (0.63–0.98)	0.77
Above median, n=7803	0.84 (0.72–0.97)
Total vegetable intake
Below median, n=6783	0.72 (0.57–0.92)	0.43
Above median, n=7491	0.86 (0.74–1.00)
Green vegetable intake
Below median, n=7639	0.77 (0.63–0.95)	0.52
Above median, n=6635	0.84 (0.72–0.99)
Lettuce vegetable intake
Below median, n=7581	0.80 (0.65–0.97)	0.73
Above median, n=6693	0.82 (0.70–0.97)

HRs for half a serving/day (one‐fourth avocado) increase in avocado intake in each subgroup category.

Multivariable model was adjusted for the following: age (y); race (Whitevs other [Black, American Indian or Alaskan Native, Asian, Native Hawaiian or Other Pacific Islander]); ancestry (Southern European/Mediterranean, other Caucasian/Scandinavian, other); alcohol intake (0, 0.1–4.9, 5.0–9.9, 10.0–14.9, and ≥15.0 g/day); smoking status (never, former, current smoker [1–14 cigarettes per day, 15–24 cigarettes per day; or ≥2 cigarettes per day]); physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9, ≥27.0 metabolic equivalent task–h/week); family history of diabetes (yes, no); family history of myocardial infarction (yes, no); family history of cancer (yes, no); baseline diabetes (yes, no); baseline hypertension or antihypertensive medication use (yes, no); baseline hypercholesterolemia or cholesterol‐lowering medication use (yes, no); multivitamin use (yes, no); aspirin use (yes, no); postmenopausal status and menopausal hormone use (premenopausal, postmenopausal [no, past, or current hormone use], in women only); total energy intake (kcal/day);body mass index (kg/m², continuous); red and processed meat, fruits and vegetables (excluding avocado), nuts, soda (caloric and low or noncaloric), whole grains, eggs, tortilla (whole and chips), breads, cheese intakes (all in quintiles; tortilla in tertiles in NHS); and trans‐fat, except the stratified factor. AHEI indicates alternative healthy eating index score; and BMI, body mass index.

^*1 serving avocado=½ avocado; ½ serving=¼ avocado.

^† n= number of cases per subgroup.