Table 4.
Incidence of Types of Cardiovascular Events and Associations With Unattributed Chest Pain in Aurum
| No. at risk | With event, n (%) |
Rate per 10 000 person‐years |
Unadjusted, HR (95% CI) |
Model 1, adjusted* HR (95% CI) |
Model 2, adjusted † HR (95% CI) |
Model 3, adjusted ‡ HR (95% CI) |
|
|---|---|---|---|---|---|---|---|
| Coronary | |||||||
| Noncoronary | 245 329 | 12 409 (5.1) | 82.85 (81.41–84.32) | 1.00 | 1.00 | 1.00 | 1.00 |
| Unattributed | 375 240 | 28 316 (7.6) | 124.32 (122.88–125.78) | 1.50 (1.47–1.53) | 1.33 (1.30–1.36) | 1.30 (1.27–1.33) | 1.30 (1.27–1.32) |
| Myocardial infarction | |||||||
| Noncoronary | 245 329 | 3945 (1.6) | 25.67 (24.88–26.48) | 1.00 | 1.00 | 1.00 | 1.00 |
| Unattributed | 375 240 | 8193 (2.2) | 34.46 (33.72–35.22) | 1.34 (1.29–1.39) | 1.16 (1.12–1.21) | 1.16 (1.12–1.20) | 1.16 (1.12–1.20) |
| Angina | 24 554 | 3207 (13.1) | 192.74 (186.18–199.52) | 7.39 (7.06–7.74) | 2.77 (2.64–2.91) | 2.46 (2.34–2.58) | 2.50 (2.38–2.62) |
| Stroke | |||||||
| Noncoronary | 245 329 | 6247 (2.6) | 40.86 (39.86–41.88) | 1.00 | 1.00 | 1.00 | 1.00 |
| Unattributed | 375 240 | 10 999 (2.9) | 46.48 (45.62–47.36) | 1.14 (1.10–1.18) | 1.00 (0.97–1.04) | 0.99 (0.96–1.03) | 0.99 (0.96–1.03) |
| Angina | 24 554 | 2292 (9.4) | 135.98 (130.53–141.67) | 3.28 (3.10–3.46) | 1.19 (1.13–1.26) | 1.08 (1.02–1.15) | 1.11 (1.05–1.18) |
HR indicates hazard ratio.
Adjusted for age, sex, race, neighborhood deprivation, year of index presentation.
Additionally adjusted for smoking status, type 1 diabetes, type 2 diabetes, family history of coronary heart disease, chronic kidney disease, atrial fibrillation, treated hypertension, migraine, rheumatoid arthritis, severe mental illness, corticosteroid medication, body mass index.
Additionally adjusted for depression/anxiety, esophageal reflux, respiratory, osteoarthritis, low back pain, neck pain, cancer.