Table 3.
Association Between Time in SBP Target Range With Clinical Outcomes Across TTR Groups
| TTR groups | |||||
|---|---|---|---|---|---|
| 0%–25% | >25%–50% | >50%–75% | >75%–100% | P for trend | |
| Primary end point | |||||
| No. (%) | 206/1055 (19.5) | 111/463 (24.0) | 99/526 (18.8) | 121/1150 (10.5) | |
| Crude model | 1.00 (Ref) | 1.30 (1.04–1.64) | 0.94 (0.74–1.20) | 0.52 (0.42–0.65) | <0.001 |
| Fully adjusted model | 1.00 (Ref) | 1.13 (0.89–1.43) | 0.85 (0.66–1.09) | 0.59 (0.46–0.75) | <0.001 |
| All‐cause mortality | |||||
| No. (%) | 159/1055 (15.1) | 88/463 (19.0) | 81/526 (15.4) | 112/1150 (9.7) | |
| Crude model | 1.00 (Ref) | 1.34 (1.04–1.74) | 1.01 (0.77–1.32) | 0.64 (0.51–0.82) | <0.001 |
| Fully adjusted model | 1.00 (Ref) | 1.12 (0.86–1.46) | 0.86 (0.65–1.13) | 0.63 (0.48–0.81) | <0.001 |
| Cardiovascular death | |||||
| No. (%) | 106/1055 (10.0) | 55/463 (11.9) | 51/526 (9.7) | 65/1150 (5.7) | |
| Crude model | 1.00 (Ref) | 1.26 (0.91–1.75) | 0.95 (0.68–1.33) | 0.56 (0.41–0.76) | <0.001 |
| Fully adjusted model | 1.00 (Ref) | 1.10 (0.78–1.53) | 0.88 (0.62–1.24) | 0.55 (0.39–0.77) | <0.001 |
| HF hospitalization | |||||
| No. (%) | 131/1055 (12.4) | 71/463 (15.3) | 66/526 (12.5) | 74/1150 (6.4) | |
| Crude model | 1.00 (Ref) | 1.30 (0.98–1.74) | 0.99 (0.73–1.32) | 0.50 (0.38–0.67) | <0.001 |
| Fully adjusted model | 1.00 (Ref) | 1.10 (0.82–1.49) | 0.87 (0.64–1.19) | 0.64 (0.47–0.88) | <0.001 |
Hazard ratios and 95% CIs were calculated with the use of the Cox proportional hazards regression model. Fully adjusted model was adjusted for age, sex, race, current smoker, left ventricular ejection fraction, estimated glomerular filtration rate, body mass index, previous HF hospitalization, diabetes, hypertension, anti‐hypertensive medication uses (inhibitors of the renin‐angiotensin, beta‐blocker, calcium‐channel blocker, diuretics), and mean corresponding SBP. HF indicates heart failure; Ref, reference; SBP, systolic blood pressure; and TTR, time in target range.