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. 2022 Mar 29;11(7):e023695. doi: 10.1161/JAHA.121.023695

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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sFRP3‐deficient post‐MI plasma releases the brake on Wnt signaling, increases FOXM1 transcriptional activity, nuclear localization of Slug, which initiates EndMT within days after MI. EndMT indicates endothelial‐to‐mesenchymal transition; FOXM1, forkhead box M1; MI, myocardial infarction; MV, mitral valve; NS, not significant; sFRP3, secreted frizzled‐related protein 3; TGFβ, transforming growth factor beta; VE, vascular endothelial; and Wnt, wingless‐related integration site.