Table 10.
Association Between Plasma Ceramides and CFR
| Adjusted model | Standardized β coefficient | P value |
|---|---|---|
| 1 | ||
| Age | −0.01 | 0.170 |
| Sex | −0.20 | 0.116 |
| Plasma ceramides 18:0/24:0 | −9.78 | 0.034 |
| 2 | ||
| Age | −0.01 | 0.169 |
| Sex | −0.22 | 0.108 |
| Hypertension | 0.09 | 0.426 |
| Diabetes | −0.06 | 0.718 |
| Hyperlipidemia | −0.04 | 0.757 |
| Lipid‐lowering drug use | 0.02 | 0.869 |
| Plasma ceramides 18:0/24:0 | −9.88 | 0.040 |
| 3 | ||
| Age | −0.01 | 0.114 |
| Sex | −0.19 | 0.180 |
| Hypertension | 0.06 | 0.599 |
| Diabetes | −0.01 | 0.964 |
| Hyperlipidemia | −0.02 | 0.873 |
| Lipid‐lowering drug use | −0.01 | 0.961 |
| LDL cholesterol | −0.01 | 0.115 |
| Non‐HDL cholesterol | 0.01 | 0.097 |
| Plasma ceramides 18:0/24:0 | −12.80 | 0.016 |
| 1 | ||
| Age | −0.01 | 0.123 |
| Sex | −0.19 | 0.148 |
| Plasma ceramides 16:0/24:0 | −5.35 | 0.014 |
| 2 | ||
| Age | −0.01 | 0.162 |
| Sex | −0.22 | 0.115 |
| Hypertension | 0.07 | 0.560 |
| Diabetes | −0.06 | 0.741 |
| Hyperlipidemia | −0.07 | 0.637 |
| Lipid‐lowering drug use | −0.03 | 0.803 |
| Plasma ceramides 16:0/24:0 | 0.016 | |
| 3 | ||
| Age | −0.01 | 0.091 |
| Sex | −0.19 | 0.185 |
| Hypertension | 0.03 | 0.783 |
| Diabetes | −0.02 | 0.941 |
| Hyperlipidemia | −0.05 | 0.735 |
| Lipid‐lowering drug use | −0.05 | 0.761 |
| LDL cholesterol | −0.00 | 0.454 |
| Non‐HDL cholesterol | −0.00 | 0.405 |
| Plasma ceramides 16:0/24:0 | −5.57 | 0.015 |
| 1 | ||
| Age | −0.01 | 0.154 |
| Sex | −0.20 | 0.117 |
| Plasma ceramides 24:1/24:0 | −1.38 | 0.044 |
| 2 | ||
| Age | −0.01 | 0.175 |
| Sex | −0.23 | 0.094 |
| Hypertension | 0.10 | 0.409 |
| Diabetes | −0.06 | 0.727 |
| Hyperlipidemia | −0.06 | 0.671 |
| Lipid‐lowering drug use | −0.02 | 0.878 |
| Plasma ceramides 24:1/24:0 | −1.42 | 0.044 |
| 3 | ||
| Age | −0.01 | 0.113 |
| Sex | −0.20 | 0.164 |
| Hypertension | 0.06 | 0.613 |
| Diabetes | −0.02 | 0.908 |
| Hyperlipidemia | −0.02 | 0.888 |
| Lipid‐lowering drug use | −0.08 | 0.601 |
| LDL cholesterol | −0.01 | 0.140 |
| Non‐HDL cholesterol | 0.01 | 0.146 |
| Plasma ceramides 24:1/24:0 | −1.74 | 0.022 |
Linear regression models consecutively adjusted for cardiovascular risk factors and lipids. HDL indicates high‐density lipoprotein; and LDL, low‐density lipoprotein.