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Time course of the effects of new quinolones on the transepithelial PD in canine tracheal mucosa in vivo. After equilibration, the tracheal mucosa was superfused with GPFX (100 μg/ml; closed circles), CPFX (100 μg/ml; closed triangles), or the vehicle alone (open circles) at time zero (upper arrows). When the PD response became stable, the superfusing solution was replaced with fresh Krebs-Henseleit solution (lower arrows). Values are means ± SE; n = 9 for each point.
