FIG. 3.
Effects of pharmacologic blocking agents on the transepithelial PD decreases induced by GPFX and CPFX. Tracheal mucosa was treated with amiloride (AML; 10−4 M), DPC (10−4 M), or DIDS (10−5 M), and then GPFX and CPFX (100 μg/ml) were added. Values are expressed as percent decreases in the PD from the baseline value. Data are means ± SE; n = 8 for each column. The symbols * (P < 0.05) and ** (P < 0.01) indicate values that are significantly different from the corresponding values for the new quinolone alone.