Table 2. Comparison of GPs’ BZD prescriptions, percentage of all BZD long-term users (≥6 months) and percentage of BZD long-term users aged 65 or more.
Unadjusted, adjusted (DDD per 1,000 inhabitants per day and percentage of BZD long-term users at baseline) and estimated ITT results for the control and intervention groups at 12-month follow-up.
| Total | ||||||||
|---|---|---|---|---|---|---|---|---|
| Intervention Mean ± SD | Control Mean ± SD | Unadjusted mean difference (95% CI) | p-value | Adjusted mean difference (95% CI) | p-value | Estimated ITT mean difference (95% CI) | p-Value | |
| Primary Outcome | ||||||||
| DDD per 1,000 inhabitants per day at baseline | 74.6 ± 31.6 | 76.9 ± 33.1 | ||||||
| DDD per 1,000 inhabitants per day at 12 months | 71.0 ± 29.9 | 76.5 ± 31.5 | −5.38 (−9.94; −0.84) | 0.020 | −3.45 (−5.09; −1.82) | <0.001 | −3.24 (−4.96; −1.53) | <0.001 |
| Secondary outcome | ||||||||
| Percentage of BZD long-term users at baseline | 9.5 ± 3.9 | 9.8 ± 3.9 | ||||||
| Percentage of BZD long-term users at 12 months | 9.1 ± 3.6 | 9.8 ± 3.8 | −0.68 (−1.23; −0.12) | 0.016 | −0.38 (−0.57; −0.18) | <0.001 | −0.36 (−0.55; −0.16) | <0.001 |
| Percentage of BZD long-term users >65 years old at baseline | 24.9 ± 8.8 | 25.3 ± 8.2 | ||||||
| Percentage of BZD long-term users >65 years old at 12 months | 23.9 ± 7.7 | 25.2 ± 7.9 | −1.28 (−2.45; −0.12) | 0.031 | −0.90 (−1.46; −0.34) | 0.002 | −0.87 (−1.44; −0.30) | 0.003 |
BZD, benzodiacepine; CI, confidence interval; DDD, defined daily dose; GP, general practitioner; ITT, intention-to-treat; SD, standard deviation.