Table 2. Sensitivity and specificity of different genetic methods in T790M mutation diagnosis in liquid biopsy.

Methods	Sensitivity	Specificity
Real-time PCR (Cobas)	60–64%	60–98%
BEAMing PCR	70,3–81%	58–68%
ddPCR	71–87%	63–100%
PNA-LNA PCR	73–89%	67–87%
NGS	80–93%	87–94%

Abbreviations: PCR–polymerase chain reaction, BEAMing PCR–beads, emulsions, amplification and magnetics PCR, ddPCR–droplet digital PCR, PNA-LNA PCR–peptide nucleic acid‐locked nucleic acid PCR, NGS–next generation sequencing