Table 2. Episodes of adverse events in included studies.
| Study | NNS+sucrose: N(Total) | NNS alone: N(Total) | Sucrose alone: N (Total) | Routine care: N(Total) | Clinical significance |
|---|---|---|---|---|---|
| Dilli, 2014 [49] | bradycardia:6(32) | bradycardia:7 (32) | - | - | bradycardia: p = 0.75 |
| tachycardia:12(32) | tachycardia:19 (32) | tachycardia: p = 0.08 | |||
| desaturations:6(32) | desaturations:7 (32) | desaturations: p = 0.75 | |||
| Gao, 2018 [44] | vomit:1(22) | vomit:1(22) | - | Vomit:1 | vomit: p = 0.800; |
| abdominal distension:1 | abdominal distension: p = 0.562 | ||||
| abdominal distension:1(22) | |||||
| Gibbins, 2002 [45] | No adverse events | oxygen desaturation:2(64) | oxygen desaturation:3(64) | - | p>0.05 |
| choke:1(64) | |||||
| O’Sullivan, 2010 [38] | bradycardia:1(20) | bradycardia:3(20) | - | - | bradycardia: p = 0.328 |
| desaturations:1(20) | desaturations:3(20) | desaturations: p = 0.328 | |||
| Thakkar, 2016 [40] | oxygen desaturation:1(45) | oxygen desaturation:1(45) | oxygen desaturation:1(45) | oxygen desaturation:2(45) | p>0.05 |