Table 2.
QoL data of the included studies
| References | Topic | Sample size for QoL analysis | QoL scale | QoL follow-up | QoL evaluation at baseline | How QoL questionnaires were administered | Proxies involved | Quality of life p value | Main findings |
|---|---|---|---|---|---|---|---|---|---|
| Tseng et al. [19] | Pravastatin in subarachnoid hemorrhage | 60 | SF 36 | 180 days | No | Direct interview | Not specified | < 0.01 | Pravastatin reduces mortality and improves QoL |
| Doig et al. [20] | Underfeeding in refeeding syndrome | 260 | SF 36 general health and physical function domains | 90 days | No | Not specified | Not specified | 0.014 | Caloric restriction improves overall survival but negatively affects QoL |
| Guidet et al. [21] | ICU triage | 1763 | SF 12 | 180 days | No | Not specified | Not specified | 0.02 | Systematic ICU admission reduces mortality but also reduces QoL in “mental” domain |
| Hanley et al. [22] | Thrombolytic removal of intraventricular hemorrhage in severe stroke | 375 | EQ-VAS/SIS | Not specified | No | Not specified | Not specified | 0.37 EQ-VAS/0.31 SIS | Irrigation of the ventricles with alteplase via an extra-ventricular drain significantly improves survival, but don’t have significant impact on QoL |
| Sprigg et al. [23] | Tranexamic acid in hyperacute primary intracerebral hemorrhage | 1808 | EQ5D HUS/EQ5D VAS | 90 days | No | Not specified | Not specified | EQ5D HUS 0.3/EQ5DVAS 0.13 | Tranexamic acid significantly reduces mortality, but it does not affect QoL |
| Zhang et al. [24] | Dexmedetomidine after noncardiac surgery | 434 | WHOQOL-BREF | 3 years | No | Telephone | Yes | < 0.0001 | Dexmedetomidine improves survival and QoL |
| Parke et al. [25] | Fluid management after cardiac surgery | 696 | EQ 5D 5L | 180 days | Yes | Not specified | Not specified | Not specified (0.023 only in pain/discomfort domain of the score) | Patients treated with a protocol-guided fluid management based on SVV after CPB had higher mortality without a significant impact on QoL |
QOL, quality of life; Proxies, people who can make healthcare decisions on behalf of patients when they are no longer able to do it by themselves; SF-36 = RAND-36, Short Form 36; SF-12, Short Form 12; ICU, intensive care unit; EQ 5D 5L, EuroQoL 5D 5L; EQ VAS, EuroQol Visual Analogue Scale; SIS, Stroke Impact Scale; EQ HUS, EuroQoL Health Utility Score; WHOQOL-BREF, World Health Organization Quality of Life-BREF; SVV, stroke volume variation; CPB, cardiopulmonary bypass