Fig. 7. PGM aggrandized glial cell activation and increased amyloid endocytosis by microglia in the hippocampal regions of APP/PS1 mice. (A–D) Fluorescent Aβ1-42 (red)/Iba1 (green)/DAPI (blue) colocalization in the cortex (A) and the DG (B), CA1 (C), CA3 (D) regions of the hippocampus in APP/PS1 mice. Scale bar = 100 μm. (E–H) Percentage of Iba1-positive microglia cell bodies that are also Aβ-positive in the cortex (E) and the DG (F), CA1 (G) and CA3 (H) regions of the hippocampus. n = 5–8 mice per group, three sections per animal. **P < 0.01 vs. APP/PS1-saline, ***P < 0.001 vs. APP/PS1-saline, ****P < 0.0001 vs. APP/PS1-saline.
