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. 2022 May 6;8(18):eabm2545. doi: 10.1126/sciadv.abm2545

Fig. 8. GPR56 expression status in microglia affects mouse behaviors.

Fig. 8.

(A) The percentage of time spent in the center of an open field, (B) total distance traveled in an open field (P = 0.80), (C) interaction time ratio in the three-chamber test, (D) total interaction time in the three-chamber test (P = 0.23), and (E) number of marbles buried in marble-burying test in wild-type (n = 17), control (Cx3cr1Cre/+; n = 14), and Gpr56 cKO mice (Gpr56f/f; Cx3cr1Cre/+; n = 13). (F) The percentage of time spent in the center of an open field, (G) total distance traveled in an open field (P = 0.09), (H) interaction time ratio in the three-chamber test, (I) total interaction time in the three-chamber test (P = 0.55), and (J) number of marbles buried in marble-burying test in control mice (PBS, Cx3cr1Cre/+; n = 16), MIA offspring [poly(I:C), Cx3cr1Cre/+; n = 19], and MIA offspring with restored expression of Gpr56 in microglia [poly(I:C), RosaGpr56/+; Cx3cr1Cre/+; n = 16). Two independent experiments. Unpaired t test for (A), (E), (F), and (J); one-way ANOVA test for (B), (D), (G), and (I); and two-way ANOVA and post hoc Bonferroni’s test for (C) and (H). #P < 0.1, *P < 0.05, **P < 0.01, and ***P < 0.001. Data are presented as means ± SEM.