Table 3.
Top 10 Reasons for Hospitalization in PS-Matched Cohorts
| Reason for Hospitalization (ICD-10 Code for Main Diagnosis) | Number of Events per 100 PYs (95% CI) | |||
|---|---|---|---|---|
| EMPA (Matched to DPP-4i) | DPP-4i | EMPA (Matched to GLP-1-RA) | GLP-1-RA | |
| N | 3100 | 3100 | 1346 | 1346 |
| Any hospitalization | 35.45 (33.73–37.20) | 45.67 (44.22–47.12) | 31.94 (29.49–34.51) | 40.14 (37.73–42.59) |
| T2DM (E11) | 2.30 (1.82–2.91) | 2.28 (1.18–2.75) | 3.26 (2.43–4.36) | 2.88 (2.16–3.83) |
| Heart failure (I50) | 1.31 (0.95–1.79) | 2.54 (2.12–3.04) | 0.76 (0.41–1.39) | 1.60 (1.09–2.35) |
| CHD (I25) | 1.58 (1.19–2.10) | 1.59 (1.27–2.00) | 0.91 (0.52–1.58) | 0.96 (0.58–1.58) |
| Angina Pectoris (I20) | 1.51 (1.13–2.02) | 1.48 (1.17–1.88) | 1.29 (0.81–2.05) | 1.02 (0.63–1.66) |
| Ischemic stroke (I63) | 1.27 (0.92–1.75) | 0.80 (0.58–1.10) | 0.53 (0.26–1.09) | 1.28 (0.83–1.97) |
| Atherosclerosis (I70) | 1.06 (0.75–1.51) | 0.86 (0.63–1.18) | 0.61 (0.31–1.19) | 0.64 (0.35–1.17) |
| Atrial fibrillation (I48) | 0.69 (0.45–1.06) | 0.97 (0.73–1.30) | 0.91 (0.52–1.58) | 0.64 (0.35–1.17) |
| Myocardial infarction (I21) | 0.93 (0.64–1.35) | 1.04 (0.78–1.38) | 1.21 (0.75–1.96) | 0.38 (0.18–0.84) |
| Dorsalgia (M54) | 0.62 (0.39–0.98) | 0.80 (0.58–1.10) | 0.91 (0.52–1.58) | 0.83 (0.49–1.42) |
| Sleep disorders (G47) | 0.86 (0.58–1.26) | 0.60 (0.41–0.87) | 0.38 (0.16–0.88) | 1.34 (0.88–2.05) |
Abbreviations: CHD, coronary heart disease; CI, confidence interval; DPP-4i, dipeptidyl peptidase-4 inhibitor; EMPA, empagliflozin; GLP-1-RA, glucagon-like peptide-1 receptor agonists; PY, person-year; T2DM, type 2 diabetes mellitus.