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. 2022 May 6;12(5):e738. doi: 10.1002/ctm2.738

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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NAT10 is overexpressed in bladder urothelial carcinoma. (A) The mRNA level of NAT10 in bladder urothelial carcinoma based on TCGA dataset. (B) Representative H&E staining and IHC images of bladder cancer tissue microarrays to show the histology and expression of NAT10 in tumours or corresponding normal tissues. (C) The relationship between NAT10 expression and clinical features in patients with bladder cancer according to the tissue microarray. (D) Effect of NAT10 expression level on BLCA patient overall survival. (E) Representative H&E staining and NAT10 IHC images in mouse bladder cancer tissues and the corresponding normal tissues and the IHC score quantification (n = 6). Scale bars: 50 μm. (F) Representative images showing NAT10 inhibitor Remodelin significantly prevented bladder tumour growing (*p < .05, n = 9)