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Thermodynamic parameters of WT RBD and its Delta mutants binding to FDA-approved Class 1 therapeutic antibody LY-CoV016 ScFv.
| RBD Variant | Kd (nM) | N | ΔH (kcal/mol) | ΔG (kcal/mol) | −TΔS (kcal/mol) |
|---|---|---|---|---|---|
| WT | 49.3 ± 10.1 | 0.9 ± 0.0 | −11.7 ± 0.1 | −9.8 ± 0.1 | 1.9 ± 0.2 |
| L452R | 23.4 ± 2.8 | 0.8 ± 0.1 | −11.9 ± 0.1 | −10.2 ± 0.1 | 1.7 ± 0.1 |
| T478K | 15.4 ± 3.0 | 0.8 ± 0.1 | −11.4 ± 0.1 | −10.5 ± 0.1 | 0.9 ± 0.2 |
| L452R/T478K | 10.8 ± 1.4 | 0.8 ± 0.1 | −12.0 ± 0.4 | −10.7 ± 0.1 | 1.3 ± 0.4 |
