In vitro inhibitory effect of quinoline-triazole based target compounds against recombinant FP2 and P. falciparum 3D7 (EC50) growth in vitro.
| S. no. | Compound | Inhibition of FP2 IC50 (μM) | Std. error | Inhibition of P. falciparum EC50 (μM) | Std. error |
|---|---|---|---|---|---|
| 1 | T1 | 26.59 | 5.45 | 49.50 | 10.54 |
| 2 | T2 | 45.08 | 9.46 | 405.64 | 398.80 |
| 3 | T3 | 25.38 | 3.18 | 159.22 | 150.16 |
| 4 | T4 | 25.64 | 4.13 | 21.89 | 4.51 |
| 5 | T5 | 107.32 | 135.24 | 66.57 | 45.08 |
| 6 | T6 | 45.78 | 18.98 | 57.86 | 183.93 |
| 7 | T7 | 16.16 | 3.03 | 49.88 | 7.41 |
| 8 | T8 | 25.37 | 1.94 | 51.71 | 8.57 |
| 9 | T9 | 20.9 | 4.15 | 146.98 | 345.29 |
| 10 | T10 | 58.46 | 19.07 | 57.63 | 14.02 |