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Clinical course. The patient received 12 courses of rituximab (RTX) and remained B-cell-depleted for months, being unable to mount an antibody response against SARS-CoV-2. She remained persistently positive for nasopharyngeal molecular swabs and with pulmonary involvement. Clinical recovery and negativization of molecular swab occurred after the administration of two units of hyperimmune convalescent plasma. SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.
