Table 4. Multivariable Cox Proportional Hazards Analysis of Overall Survival.

Variables	Multivariable analysisa
	Hazard ratio (95% CI)	P value
Gastrointestinal adverse events (yes vs. no)
All patients	0.528 (0.331 - 0.844)	0.008
Cancer subtypes
Melanoma	0.339 (0.119 - 0.962)	0.042
Lung cancer	1.072 (0.519 - 2.212)	0.85
Renal cell carcinoma	0.665 (0.202 - 2.185)	0.50
All other cancers	0.656 (0.240 - 1.793)	0.41

^aAnalysis was adjusted for age (per 1-year increase) and immunotherapy (mono- vs. dual-therapy). CI: confidence interval.