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. 2022 May 6;82(5):517–527. doi: 10.1055/a-1749-5391

Table 3  Association of use of ondansetron or any prescription antiemetic versus use of cannabis with relief of symptoms and subsequent weight gain, among all respondents and those who did or did not lose weight during the pregnancy, odds ratio* (95% confidence interval). Odds ratios are adjusted for age.

Agent Used All participants (n = 550) Those who lost weight (n = 464) Those who did not lose weight (n = 70)
* Adjusted for age.
16 participants did not provide information about weight loss.
Relief of symptoms of nausea and vomiting of pregnancy
  • Cannabis

  • Ondansetron

  • Any prescription antiemetic

1.0 (ref)
1.17 (0.49 – 2.76)
0.36 (0.17 – 0.65)
1.0 (ref)
1.30 (0.51 – 3.32)
0.32 (0.15 – 0.60)
1.0 (ref)
0.57 (0.01 – 11.92)
0.71 (0.03 – 5.25)
Weight gain within two weeks of starting treatment
  • Cannabis

  • Ondansetron

  • Any prescription antiemetic

1.0 (ref)
0.26 (0.13 – 0.51)
0.21 (0.12 – 0.36)
1.0 (ref)
0.21 (0.10 – 0.44)
0.19 (0.10 – 0.33)
1.0 (ref)
0.63 (0.02 – 9.16)
0.42 (0.02 – 4.98)