TABLE 3.
Rate Ratios of Unintentional Fatal or Nonfatal Overdose (OD) Among OxyContin and Secondary Comparator Opioid Use Before and After the Reformulation, by Database
| Rate Ratio for Postreformulation vs. Prereformulation Periods | Ratio of Rate Ratios for Comparator Opioids vs. OxyContin | |||||
|---|---|---|---|---|---|---|
| Adjusted Rate Ratio | 95% LCL | 95% UCL | Adjusted Ratio of Rate Ratios | 95% LCL | 95% UCL | |
| Medicaid | ||||||
| Any nonoverlapping use* | ||||||
| OxyContin | 0.85 | 0.73 | 0.98 | Ref | — | — |
| ER oxymorphone | 1.06 | 0.81 | 1.38 | 1.25 | 0.92 | 1.69 |
| IR oxycodone SE | 0.92 | 0.83 | 1.01 | 1.08 | 0.9 | 1.29 |
| IR hydromorphone | 0.90 | 0.76 | 1.07 | 1.06 | 0.85 | 1.33 |
| Use without concomitant opioids (“only use”) | ||||||
| OxyContin | 0.80 | 0.63 | 1.01 | Ref | — | — |
| ER oxymorphone | 1.01 | 0.66 | 1.54 | 1.27 | 0.79 | 2.06 |
| IR oxycodone SE | 0.94 | 0.83 | 1.05 | 1.18 | 0.90 | 1.53 |
| IR hydromorphone | 1.00 | 0.80 | 1.25 | 1.26 | 0.91 | 1.74 |
| MarketScan | ||||||
| Any nonoverlapping use* | ||||||
| OxyContin | 0.69 | 0.55 | 0.86 | Ref | — | — |
| ER oxymorphone | 1.74 | 0.94 | 3.24 | 2.54 | 1.31 | 4.92 |
| IR oxycodone SE | 1.20 | 0.94 | 1.54 | 1.75 | 1.26 | 2.44 |
| IR hydromorphone | 1.03 | 0.72 | 1.47 | 1.50 | 0.99 | 2.29 |
| Use without concomitant opioids (“only use”) | ||||||
| OxyContin | 0.64 | 0.44 | 0.94 | Ref | — | — |
| ER oxymorphone | 2.76 | 0.84 | 9.08 | 4.30 | 1.23 | 15.04 |
| IR oxycodone SE | 1.29 | 0.96 | 1.73 | 2.01 | 1.24 | 3.25 |
| IR hydromorphone | 0.83 | 0.54 | 1.25 | 1.29 | 0.73 | 2.26 |
| HIRD | ||||||
| Any nonoverlapping use* | ||||||
| OxyContin | 0.59 | 0.44 | 0.80 | Ref | — | — |
| ER oxymorphone | 0.72 | 0.41 | 1.26 | 1.21 | 0.64 | 2.28 |
| IR oxycodone SE | 0.98 | 0.71 | 1.35 | 1.65 | 1.07 | 2.53 |
| IR hydromorphone | 0.78 | 0.53 | 1.16 | 1.32 | 0.81 | 2.14 |
| Use without concomitant opioids (“only use”) | ||||||
| OxyContin | 0.48 | 0.30 | 0.78 | Ref | — | — |
| ER oxymorphone | 1.00 | 0.35 | 2.87 | 2.08 | 0.65 | 6.66 |
| IR oxycodone SE | 1.00 | 0.68 | 1.48 | 2.09 | 1.13 | 3.84 |
| IR hydromorphone | 0.80 | 0.49 | 1.28 | 1.66 | 0.86 | 3.19 |
*
Treatment episodes that had overlapping use of more than 1 secondary comparator or any primary comparators or OxyContin at the same time were excluded.
ER indicates extended release; HIRD, HealthCore Integrated Research Database; IR, immediate release; LCL, lower confidence limit; SE, single entity; UCL, upper confidence limit.