Table 2.
Effects of IH on pharmacokinetic parameters of warfarin (mean ± SD, n = 10).
| Parameters | Normoxia (n = 5) | IH (n = 5) |
|---|---|---|
| C max (ng/L) | 607.03 ± 16.20 | 618.80 ± 3.86 |
| T 1/2 (h) | 28.10 ± 7.20 | 23.97 ± 2.63 |
| AUC0–144 h (mg/h/L) | 27684.34 ± 1181.92 | 27358.69 ± 1339.80 |
| AUC0-∞ (mg/h/L) | 28820.98 ± 1837.82 | 28112.48 ± 1347.09 |
| CL (L/h/kg) | 0.001 ± 0.00 | 0.001 ± 0.00 |
The data are shown as means ± SD. AUC0-∞: area under curve-time profile curve from time 0 to infinity; AUC0-t: area under curve-time profile curve from time 0 to end. CL: clearance; Cmax: peak of maximum concentration; T1/2: half-life.