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. 2022 Feb 23;43(18):1702–1711. doi: 10.1093/eurheartj/ehac093

Figure 3.

Figure 3

Ten-year and lifetime risk of coronary artery disease according to clinical and polygenic risk categories. (A) Ten-year risk of coronary artery disease obtained from the recalibrated clinical risk and metaPRS model with follow-up time as the time scale. (B) Lifetime risk of coronary artery disease (till 80 years of age) obtained from the recalibrated clinical risk and metaPRS model accounting for competing risk with age as the time scale. Participants were stratified into low (<2.5%), intermediate (2.5–4.4%), high (4.5–5.9%), and very high (≥6%) 10-year risk of CAD categories, approximately equating to the atherosclerotic cardiovascular disease risk of <5, 5–9.9, 10–14.9, and ≥15%. According to the risk assessment guideline from China, the established treatment threshold for atherosclerotic cardiovascular disease is the 10-year risk of atherosclerotic cardiovascular disease of 10%. CAD, coronary artery disease; ASCVD, atherosclerotic cardiovascular disease; PRS, polygenic risk score.